North East and North Cumbria
ICS Formulary
 
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9 Nutrition and blood
09-01 Anaemias and some other blood disorders

Exagamglogene Autotemcel Casgevy®
Formulary
  • 4-13 × 106 cells/mL dispersion for infusion
  • Approved for treating transfusion-dependent beta-thalassaemia in people 12 years and over in line with NICE
  • Approved (in line with NICE) for treating sickle cell disease (SCD) in people 12 years and over:
    • who have:
      • recurrent vaso-occlusive crises (VOCs) and
      • a βS/βS, βS/β+ or βS/β0 genotype and
    • when haematopoietic stem cell transplant (HSCT) is suitable, but a human leukocyte antigen-matched related haematopoietic stem cell donor is not available.
Link  NICE TA1003 : Exagamglogene autotemcel for treating transfusion-dependent beta-thalassaemia in people 12 years and over
Link  NICE TA1044: Exagamglogene autotemcel for treating severe sickle cell disease in people 12 years and over

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