North East and North Cumbria
ICS Formulary
 
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6 Endocrine system
06-07-02 Drugs affecting gonadotrophins

Northern Region Gender Dysphoria Service

General Guidelines For The Use Of Hormone Treatment In Gender Dysphoria


Leuprorelin
First Choice
  • Approved formualtions include 3.75mg and 11.25mg pre filled syringes (also see section 8.3.4.2).

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Linzagolix Yselty®
Formulary
  • 100 mg , 200 mg Tablets
  • Approved for treating moderate to severe symptoms of uterine fibroids in adults of reproductive age in line with NICE
  • Commissioning: ICS (adults), NHSE (16-17 year olds)

Prescribing to remain with the specialist until DXA scans have been performed and any necessary action taken.

Prescribing may be transferred to primary care when no further DXA scans are required.

Link  NICE TA996 : Linzagolix for treating moderate to severe symptoms of uterine fibroids

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Nafarelin Nasal Spray
Formulary
  •  200 micrograms of nafarelin base per spray.
  • Red when used as part of IVF.

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Relugolix–estradiol–norethisterone acetate Ryeqo®
Formulary
  • Approved as an option for treating moderate to severe symptoms of uterine fibroids in adults of reproductive age in line with NICE
  • Approved as an option for treating symptoms of endometriosis in adults of reproductive age who have had medical or surgical treatment for endometriosis in line with NICE

Prescribing to remain with the specialist until DXA scans have been performed and any necessary action taken.

Prescribing may be transferred to primary care when no further DXA scans are required.

Link  NICE TA1057: Relugolix–estradiol–norethisterone for treating symptoms of endometriosis
Link  NICE TA832: Relugolix–estradiol–norethisterone acetate for treating moderate to severe symptoms of uterine fibroids

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Cetrorelix
Formulary

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Danazol 100mg and 200mg capsules
Formulary

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Ganirelix Ovamex®
Formulary
  • 0.25mg/0.5ml solution for injection in pre-filled syringe
  • For use as an additional option for use in IVF.

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Goserelin
Formulary
  • The following goserelin formulations are approved for use 3.6mg & 10.8mg injections (also see section 8.3.4.2). 
  • Note: leuprorelin is now substantially less expensive than goserelin

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Triptorelin
Formulary
  • The following formulations are approved for use in treating precocious puberty:
    • Gonapeptyl Depot® 3.75mg injection;
    • Decapeptyl SR®11.25mg injection.

  • Refer to Chapter 8 - Gonadorelin analogues for the treatment of prostate cancer. The following strengths are approved:
    • 3mg, 11.25mg and 22.5mg

 


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