North East and North Cumbria
ICS Formulary
 
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8 Malignant disease and immunosuppression
08-03-04-02 Anti-androgens

Abiraterone
Formulary

Approved in line with NICE for:

  • castration-resistant metastatic prostate cancer 
  • Approved for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated in line with NICE and NHS England Commissioning Policy
  • treating newly diagnosed high-risk hormone‑sensitive metastatic prostate cancer
Link  NICE TA259: Abiraterone for castration resistant prostate cancer
Link  NICE TA387:Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
Link  NICE TA1110: Abiraterone (originator and generics) for treating newly diagnosed high-risk hormone‑sensitive metastatic prostate cancer

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Apalutamide  Erleada®
Formulary
  • 60mg tablets
  • Approved for treating hormone‑relapsed non‑metastatic prostate cancer that is at high risk of metastasising in adults in line with NICE
  • Approved for treating hormone-sensitive metastatic prostate cancer in adults in line with NICE, only if:
    • docetaxel is not suitable

 

Link  NICE TA740: Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancer
Link  NICE TA741: Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer

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Bicalutamide
Formulary

Initiate with specialist advice.


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Cyproterone
Formulary

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Darolutamide Nubeqa®
Formulary

300mg tablets

Approved in line with NICE for

  • treating hormone-relapsed prostate cancer in adults at high risk of developing metastatic disease 
  • with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancer in line with NICE and NHSE Specialised Commissioning guidance
  • with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer

 

Link  NICE TA660: Darolutamide with androgen deprivation therapy for treating hormone-relapsed non-metastatic prostate cancer
Link  NICE TA903: Darolutamide with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancer
Link  NICE TA1109: Darolutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancer

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Enzalutamide
Formulary
  • Approved for use in adults with metastatic hormone-relapsed prostate cancer, who have not had chemotherapy in line with NICE.
  • Approved for treating hormone-sensitive metastatic prostate cancer in line with NICE
Link  NICE TA316: Enzalutamide for prostate cancer
Link  NICE TA377: Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
Link  NICE TA712: Enzalutamide for treating hormone-sensitive metastatic prostate cancer

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Flutamide
Formulary

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