North East and North Cumbria
ICS Formulary
4 Central nervous system
04-03-03 Selective serotonin re-uptake inhibitors
Citalopram
First Choice
Please note maximum doses
Adults = 40mg
Elderly = 20mg
MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (July 2016): Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use
Fluoxetine
First Choice
10mg & 20mg capsules
20mg dispersible tablets
first choice for patients unable to use the capsules
20mg/5ml oral solution
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
Paroxetine
First Choice
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
Sertraline
First Choice
25mg, 50mg, 100mg, 150mg & 200mg tablets
100mg/5ml
concentrate
for oral solution (Thame)
Approved for patients who are unable to take a solid dose form or who require small doses
Must be diluted prior to use
. Please refer to SPC for list of specified drinks
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
Escitalopram
Formulary
MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
Links
MHRA Drug Safety Alert (Feb 2015): Drugs and driving: blood concentration limits set for certain drugs
MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
MHRA Drug Safety Update (July 2016): Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use
NENC Palliative and End of Life Care Symptom Control Guidelines
NICE CG192: Antenatal and postnatal mental health
NICE CG31: Obsessive-compulsive disorder
NICE CG91: Depression in adults with a chronic physical health problem: recognition and management
NICE NG116: Post-traumatic stress disorder
NICE NG134: Depression in children and young people: identification and management
NICE NG206: Chronic fatigue syndrome / Myalgic encephalomyelitis
NICE NG222: Depression in adults: treatment and management
NICE NG62: Cerebral palsy in under 25s: assessment and management
NICE TA367 - Vortioxetine for treating major depressive episodes
TEWV - Medicines Optimisation – Interactive Guide
TEWV Depression medication pathway for adults
TEWV Guidelines
TEWV Safe Transfer of Prescribing Guidance
Key
Full Site