North East and North Cumbria
ICS Formulary
 
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21 Palliative Care Formulary

NENC Palliative and End of Life Care Symptom Control Guidelines for cancer and non-cancer patients

NICE CG140: Palliative care for adults: strong opioids for pain relief

NICE CSG4: Improving supportive and palliative care for adults with cancer

21-01 Pain

Alfentanil
Formulary

1mg in 2ml, 5mg in 10ml & 5mg in 1ml injection ampoules - approved for initiation by specialists in palliative care 


Controlled Drug  Green plus View adult BNF  View SPC online  View childrens BNF
Codeine
Formulary

First line: 15mg tablets

Second line: 30mg tablets

 

Codeine linctus 15mg/5ml - approved for cough suppression in palliative care patients unable to take tablets

Link  MHRA Drug Safety Update (February 2024): Codeine linctus (codeine oral solutions): reclassification to prescription-only medicine

Green View adult BNF  View SPC online  View childrens BNF
Ketamine
Formulary

 



 


Controlled Drug  Red View adult BNF  View SPC online  View childrens BNF
Buprenorphine
Formulary
  • 200microgram sublingual tablets
  • 300microgram in 1ml injection
  • Buprenorphine patches (Preferred brand - Butec®) are approved for use in palliative care when fentanyl 12 microgram/hr transdermal patches exceed the patient’s analgesic requirements.

Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF
Fentanyl
Formulary
  • 12, 25, 37.5, 50, 75 & 100 microgram/hour transdermal patches Green Traffic Light
    • Prescribe by brand. Mezolar® has replaced Matrifen® as the first choice brand. Patients who currently use Matrifen® can continue to do so if managing well.
  • Fentanyl sublingual tablets (Abstral®)  Green plus restricted to use for breakthrough / rescue pain relief in palliative care on recommendation of a pain specialist or palliative care team.
Link  MHRA Drug Safety Update (Oct 2018): Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children
Link  MHRA Drug Safety Update (Sep 2020): Transdermal fentanyl patches for non-cancer pain: do not use in opioid-naive patients
Link  Transdermal fentanyl – MHRA Drug Safety Update (July 2014): Transdermal fentanyl “patches”: reminder of potential life threatening harm from accidental exposure, especially in children

Controlled Drug  View adult BNF  View SPC online  View childrens BNF
Oxycodone
Formulary
  • Approved only for use in patients who are intolerant of morphine. Green
  • Note: Oxycodone 50mg in 1ml injection  is also approved for use, but is restricted to controlled circumstances in palliative patients following risk assessment by individual organisations.Green Traffic Light
  • The OxyPro® branded generic is preferred (most cost effective option). 
  • The oral solution should be used instead of immediate release tablets. 

Controlled Drug  View adult BNF  View SPC online  View childrens BNF