netFormulary

North East and North Cumbria
ICS Formulary

2 Cardiovascular system

02-10-02 Fibrinolytic drugs

Primary Percutaneous Coronary Intervention (PCI) is now preferred to thrombolysis in patients with myocardial infarction with ST segment elevation (STEMI).

Streptokinase

First Choice

Alteplase

Formulary

10mg, 20mg, and 50mg injections.
Also approved for stoke in accordance with NICE guidance.
2mg in 2ml injection - approved for unblocking intravenous lines, mainly in paediatric dialysis patients.

NICE NG128: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management

NICE TA264: Ischaemic stroke (acute) - alteplase

Tenecteplase Metalyse^®

Formulary

5,000 units (25mg) powder and solvent for solution for injection
10,000 units (50mg) powder and solvent for solution for injection
Approved or treating acute ischaemic stroke in adults in line with NICE

NICE TA990: Tenecteplase for treating acute ischaemic stroke

Urokinase

Formulary

Links

Academic Health Science Network (North East and North Cumbria) - Atrial Fibrilation
NICE CG95: Recent-onset chest pain of suspected cardiac origin: assessment and diagnosis
NICE NG128: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management
NICE NG128: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management
NICE NG148: Acute kidney injury: prevention, detection and management
NICE NG191: COVID-19 rapid guideline: managing COVID-19
NICE TA264: Ischaemic stroke (acute) - alteplase
NICE TA52: Myocardial infarction - thrombolysis
NICE TA990: Tenecteplase for treating acute ischaemic stroke

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