North East and North Cumbria
ICS Formulary
1 Gastro-intestinal system
01-02 Other antispasmodics
Mebeverine
Formulary
135mg tablets
50mg/5ml oral suspension should only be used in patients unable to use solid dosage forms
Do not prescribe 200mg MR capsules (see below)
Peppermint Oil
Colpermin
®
Formulary
Peppermint water
Formulary
Mebeverine
Non Formulary
200mg modified-release capsules
For preferred preparations, see main formulary entry above
Links
Guidelines for the Management of Adults with Asymptomatic Liver Blood Test Abnormalities
MHRA Drug Safety Update (Feb 2017): Hyoscine butylbromide (Buscopan) injection: risk of serious adverse effects in patients with underlying cardiac disease
MHRA DSU (Aug 2013): Metoclopramide: risk of neurological adverse effects
MHRA DSU (Dec 2019): Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
MHRA DSU (July 2026): Domperidone: new contraindication in patients with phaeochromocytoma due to the risk of severe hypertension
MHRA DSU (May 2014): Domperidone: risk of cardiac side effects
NICE CG49: Faecal incontinence
NICE CG99: Constipation in children and young people
NICE NG71: Parkinson’s disease in adults
NTAG: Transanal irrigation (TAI) systems (Peristeen Plus®, Aquaflush®, and QuFora®) for neurogenic bowel dysfunction, chronic constipation and chronic faecal incontinence
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