North East and North Cumbria
ICS Formulary
 
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1 Gastro-intestinal system
01-02 Antimuscarinics

Hyoscine Butylbromide Buscopan®
First Choice

  • First choice for respiratory secretions
Link  MHRA Drug Safety Update (Feb 2017): Hyoscine butylbromide (Buscopan) injection: risk of serious adverse effects in patients with underlying cardiac disease

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Propantheline
Formulary

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Dicycloverine
Formulary

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Glycopyrronium bromide
Restricted
  •  1mg/5mL oral solution sugar free
    • Approved for the first line treatment of uncontrolled oral/respiratory secretions/sialorrhoea in Motor Neurone Disease/Home Ventilation patients who have cognitive impairment.
    • Approved for second line treatment of uncontrolled oral/respiratory secretions/sialorrhoea in Motor Neurone Disease/Home Ventilation  patients who have failed other treatment options such as hyoscine patches or who have intolerance to other agents.
    • Approved for management of drooling of saliva in people with Parkinson’s disease in line with NICE 
  • 2mg/5ml oral solution (Sialanar®)
    • approved for the treatment of severe sialorrhoea in children and adolescents with chronic neurological disorders.
Link  NICE NG71: Parkinson’s disease in adults

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